Greetings, Unregistered.

Please note: you'll need to uninstall iTunes 7 before installing iTunes 8 for TuneUp to work.
If you didn't catch this notice in time, then you must uninstall iTunes 8 and Tuneup...and then reinstall both.
You'll know it's not working because TuneUp can't save clean data or cover art and Now Playing doesn't display anything.

Regards, The TuneUp Team